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Risk of Guillain-Barré syndrome after seasonal influenza vaccination and influenza health-care encounters: a self-controlled study.

Identifieur interne : 000328 ( Main/Exploration ); précédent : 000327; suivant : 000329

Risk of Guillain-Barré syndrome after seasonal influenza vaccination and influenza health-care encounters: a self-controlled study.

Auteurs : Jeffrey C. Kwong [Canada] ; Priya P. Vasa ; Michael A. Campitelli ; Steven Hawken ; Kumanan Wilson ; Laura C. Rosella ; Therese A. Stukel ; Natasha S. Crowcroft ; Allison J. Mcgeer ; Lorne Zinman ; Shelley L. Deeks

Source :

RBID : pubmed:23810252

Descripteurs français

English descriptors

Abstract

BACKGROUND

The possible risk of Guillain-Barré syndrome from influenza vaccines remains a potential obstacle to achieving high vaccination coverage. However, influenza infection might also be associated with Guillain-Barré syndrome. We aimed to assess the risk of Guillain-Barré syndrome after seasonal influenza vaccination and after influenza-coded health-care encounters.

METHODS

We used the self-controlled risk interval design and linked universal health-care system databases from Ontario, Canada, with data obtained between 1993 and 2011. We used physician billing claims for influenza vaccination and influenza-coded health-care encounters to ascertain exposures. Using fixed-effects conditional Poisson regression, we estimated the relative incidence of hospitalisation for primary-coded Guillain-Barré syndrome during the risk interval compared with the control interval.

FINDINGS

We identified 2831 incident admissions for Guillain-Barré syndrome; 330 received an influenza vaccine and 109 had an influenza-coded health-care encounter within 42 weeks before hospitalisation. The risk of Guillain-Barré syndrome within 6 weeks of vaccination was 52% higher than in the control interval of 9-42 weeks (relative incidence 1·52; 95% CI 1·17-1·99), with the greatest risk during weeks 2-4 after vaccination. The risk of Guillain-Barré syndrome within 6 weeks of an influenza-coded health-care encounter was greater than for vaccination (15·81; 10·28-24·32). The attributable risks were 1·03 Guillain-Barré syndrome admissions per million vaccinations, compared with 17·2 Guillain-Barré syndrome admissions per million influenza-coded health-care encounters.

INTERPRETATION

The relative and attributable risks of Guillain-Barré syndrome after seasonal influenza vaccination are lower than those after influenza illness. Patients considering immunisation should be fully informed of the risks of Guillain-Barré syndrome from both influenza vaccines and influenza illness.

FUNDING

Canadian Institutes of Health Research.


DOI: 10.1016/S1473-3099(13)70104-X
PubMed: 23810252


Affiliations:


Links toward previous steps (curation, corpus...)


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<p>The possible risk of Guillain-Barré syndrome from influenza vaccines remains a potential obstacle to achieving high vaccination coverage. However, influenza infection might also be associated with Guillain-Barré syndrome. We aimed to assess the risk of Guillain-Barré syndrome after seasonal influenza vaccination and after influenza-coded health-care encounters.</p>
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<p>We used the self-controlled risk interval design and linked universal health-care system databases from Ontario, Canada, with data obtained between 1993 and 2011. We used physician billing claims for influenza vaccination and influenza-coded health-care encounters to ascertain exposures. Using fixed-effects conditional Poisson regression, we estimated the relative incidence of hospitalisation for primary-coded Guillain-Barré syndrome during the risk interval compared with the control interval.</p>
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<p>We identified 2831 incident admissions for Guillain-Barré syndrome; 330 received an influenza vaccine and 109 had an influenza-coded health-care encounter within 42 weeks before hospitalisation. The risk of Guillain-Barré syndrome within 6 weeks of vaccination was 52% higher than in the control interval of 9-42 weeks (relative incidence 1·52; 95% CI 1·17-1·99), with the greatest risk during weeks 2-4 after vaccination. The risk of Guillain-Barré syndrome within 6 weeks of an influenza-coded health-care encounter was greater than for vaccination (15·81; 10·28-24·32). The attributable risks were 1·03 Guillain-Barré syndrome admissions per million vaccinations, compared with 17·2 Guillain-Barré syndrome admissions per million influenza-coded health-care encounters.</p>
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<b>INTERPRETATION</b>
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<p>The relative and attributable risks of Guillain-Barré syndrome after seasonal influenza vaccination are lower than those after influenza illness. Patients considering immunisation should be fully informed of the risks of Guillain-Barré syndrome from both influenza vaccines and influenza illness.</p>
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<PubMedPubDate PubStatus="medline">
<Year>2013</Year>
<Month>11</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
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<PublicationStatus>ppublish</PublicationStatus>
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<ArticleId IdType="pii">S1473-3099(13)70104-X</ArticleId>
<ArticleId IdType="doi">10.1016/S1473-3099(13)70104-X</ArticleId>
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<list>
<country>
<li>Canada</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Campitelli, Michael A" sort="Campitelli, Michael A" uniqKey="Campitelli M" first="Michael A" last="Campitelli">Michael A. Campitelli</name>
<name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name>
<name sortKey="Deeks, Shelley L" sort="Deeks, Shelley L" uniqKey="Deeks S" first="Shelley L" last="Deeks">Shelley L. Deeks</name>
<name sortKey="Hawken, Steven" sort="Hawken, Steven" uniqKey="Hawken S" first="Steven" last="Hawken">Steven Hawken</name>
<name sortKey="Mcgeer, Allison J" sort="Mcgeer, Allison J" uniqKey="Mcgeer A" first="Allison J" last="Mcgeer">Allison J. Mcgeer</name>
<name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name>
<name sortKey="Stukel, Therese A" sort="Stukel, Therese A" uniqKey="Stukel T" first="Therese A" last="Stukel">Therese A. Stukel</name>
<name sortKey="Vasa, Priya P" sort="Vasa, Priya P" uniqKey="Vasa P" first="Priya P" last="Vasa">Priya P. Vasa</name>
<name sortKey="Wilson, Kumanan" sort="Wilson, Kumanan" uniqKey="Wilson K" first="Kumanan" last="Wilson">Kumanan Wilson</name>
<name sortKey="Zinman, Lorne" sort="Zinman, Lorne" uniqKey="Zinman L" first="Lorne" last="Zinman">Lorne Zinman</name>
</noCountry>
<country name="Canada">
<noRegion>
<name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name>
</noRegion>
</country>
</tree>
</affiliations>
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